Those with higher vitamin D levels tend to have lower rates of obesity, diabetes, and hypertension, but is it cause and effect? Interventional trials finally put vitamin D to the test. My last in-depth video series on vitamin D was done more than four years ago—as in 15,950 papers ago. I had a lot of catching up to do.
Review articles like this continue to be published, touting vitamin D as a veritable cure-all. The vitamin D receptor is found in most tissues in the body, including the brain. Upwards of 2,000 genes may be regulated by vitamin D. Within 24 hours of vitamin D exposure, you can change the expression of hundreds of genes.
The term vitamin is actually a misnomer. Vitamins, by definition, cannot be synthesized within our bodies. But we can make all the D we need with sufficient sun exposure. D is not a vitamin, but a hormone, produced by our skin in response to sunlight exposure. And it’s not just a hormone of calcium regulation and bone health, but a hormone of fertility and immunity and brain function. But is it a panacea, or a false prophet?
Remember when vitamin E was the vitamin du jour, touted as curative for many clinical disorders. “Vitamin E: the radical protector,” with supplement sales, in general, forming a billion-dollar business to capitalize on the public’s fears. After all, those with low levels of vitamin E in their blood had a 50% higher cancer risk. Hey, and what about vitamin A or beta carotene? After all, people who eat lots of greens and sweet potatoes and other beta carotene-rich foods have a lower risk of cancer; so, we should give people beta carotene pills. But when they were put to the test, beta carotene pills increased cancer rates. Beta carotene, vitamin A, and vitamin E supplements may increase mortality, in effect potentially paying to shorten our lifespan. So, you can understand the skepticism in the medical community regarding claims about vitamin D, which is now enjoying its moment in the sun.
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